Structure of PDB 8ugb Chain A Binding Site BS01

Receptor Information
>8ugb Chain A (length=811) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EEVEKFLDSNVSFAKQYYNLRYRAKVISDLLGPREAAVDFSNYHALNSVE
ESEIIFDLLRDFQDNLQAEKCVFNVMKKLCFLLQADRMSLFMYRARNGIA
ELATRLFNVHKDAVLEECLVAPDSEIVFPLDMGVVGHVALSKKIVNVPNT
EEDEHFCDFVDTLTEYQTKNILASPIMNGKDVVAIIMVVNKVDGPHFTEN
DEEILLKYLNFANLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIE
RQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPPYAGPR
TPDGREINFYKVIDYILHGKEDIKVIPNPPPDHWALVSGLPTYVAQNGLI
CNIMNAPSEDFFAFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNR
KDGKPFDEMDETLMESLTQFLGWSVLNPDTYELMNKLENRKDIFQDMVKY
HVKCDNEEIQTILKTREVYGKEPWECEEEELAEILQGELPDADKYEINKF
HFSDLPLTELELVKCGIQMYYELKVVDKFHIPQEALVRFMYSLSKGYRRI
TYHNWRHGFNVGQTMFSLLVTGKLKRYFTDLEALAMVTAAFCHDIDHRGT
NNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHE
HAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYETQQEWTQYMMLDQT
RKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQN
PIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNR
KEWKALADEYE
Ligand information
>8ugb Chain D (length=23) Species: 9913 (Bos taurus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
SATRVMGGPVTPRKGPPKFKQRQ
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8ugb Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
Resolution3.0 Å
Binding residue
(original residue number in PDB)		N103 F113 P128 D129 S130 E131 I132 V133 D137 M138 F165 L169 T170 E171 Y349 G354 L355 I356 C357 M360 N361 V391
Binding residue
(residue number reindexed from 1)		N97 F107 P122 D123 S124 E125 I126 V127 D131 M132 F159 L163 T164 E165 Y343 G348 L349 I350 C351 M354 N355 V385
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
Biological Process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0019933 cAMP-mediated signaling
GO:0060041 retina development in camera-type eye
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005886 plasma membrane
GO:0042622 photoreceptor outer segment membrane
GO:0042995 cell projection
GO:0097381 photoreceptor disc membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8ugb, PDBe:8ugb, PDBj:8ugb
PDBsum8ugb
PubMed38159849
UniProtP11541|PDE6A_BOVIN Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Gene Name=PDE6A)

[Back to BioLiP]