Structure of PDB 8ud4 Chain A Binding Site BS01

Receptor Information
>8ud4 Chain A (length=346) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLENVAFNVVNKGHFDGQQGEVPVSIINNTVYTKVDGVDVELFENKTTLP
VNVAFELWAKRNIKPVPEVKILNNLGVDIAANTVIWDYKRDAPAHISTIG
VCSMTDIAKKPTETICAPLTVFFDGRVDGQVDLFRNARNGVLITEGSVKG
LQPSVGPKQASLNGVTLIGEAVKTQFNYYKKVDGVVQQLPETYFTQSRNL
QEFKPRSQMEIDFLELAMDEFIERYKLEGYAFEAIVYGDFSHSQLGGLHL
LIGLAKRFKESPFELEDFIPMDSTVKNYFITDAQTGSSKCVCSVIDLLLD
DFVEIIKSQDLSVVSKVVKVTIDYTEISFMLWCKDGHVETFYPKLQ
Ligand information
>8ud4 Chain G (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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.......................
Receptor-Ligand Complex Structure
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PDB8ud4 Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		Q244 H249 K289 V291 S293 W332 K334 E339 T340 Y342
Binding residue
(residue number reindexed from 1)		Q244 H249 K289 V291 S293 W332 K334 E339 T340 Y342
Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.50: mRNA guanylyltransferase.
3.1.13.-
3.4.19.12: ubiquitinyl hydrolase 1.
3.4.22.-
3.4.22.69: SARS coronavirus main proteinase.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
4.6.1.-
External links
PDB RCSB:8ud4, PDBe:8ud4, PDBj:8ud4
PDBsum8ud4
PubMed38613382
UniProtP0DTD1|R1AB_SARS2 Replicase polyprotein 1ab (Gene Name=rep)

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