Structure of PDB 8ucu Chain A Binding Site BS01

Receptor Information
>8ucu Chain A (length=868) Species: 8355 (Xenopus laevis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QVFRFYWLDAYEDQYSQPGVVYLFGKVWIESADAYVSCCVSVKNIERTVY
LLPRENRVQLSTGKDTGAPVSMMHVYQEFNEAVAEKYKIMKFKSKKVDKD
YAFEIPDVPASSEYLEVRYSADSPQLPQDLKGETFSHVFGTNTSSLELFL
LSRKIKGPSWLEIKSPQLSSQPMSWCKVEAVVTRPDQVSVVKDLAPPPVV
VLSLSMKTVQNAKTHQNEIVAIAALVHHTFPLDKAPPQPPFQTHFCVLSK
LNDCIFPYDYNEAVKQKNANIEIALTERTLLGFFLAKIHKIDPDVIVGHD
IYGFDLEVLLQRINSCKVPFWSKIGRLRRSVMPKLGGRSGFAERNAACGR
IICDIEISAKELIRCKSYHLSELVHQILKAERVVIPPENIRNAYNDSVHL
LYMLENTWIDAKFILQIMCELNVLPLALQITNIAGNVMSRTLMGGRSERN
EYLLLHAFTENNFIVPDKPVAAYAGGLVLEPKVGFYDKFILLLDFNSLYP
SIIQEYNICFTTVHREADEIPELPHSDLEMGILPREIRKLVERRRHVKQL
MKQPDLNPDLYLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTH
QGREILLHTKEMVQKMNLEVIYGDTDSIMINTNCNNLEEVFKLGNRVKSE
INKSYKLLEIDIDGIFKSLLLLKKKKYAALTVEPTGDGKYVTKQELKGLD
IVRRDWCELAKQAGNYVISQILSDQPRDSIVENIQKKLTEIGENVTNGTV
PITQYEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTISYV
ICQDGSNLSASQRAYAQEQLQKQENLSIDTQYYLSQQVHPVVARICEPID
GIDSALIAMWLGLDPSQF
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ucu A mechanistic model of primer synthesis from catalytic structures of DNA polymerase alpha-primase.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		F679 R778 R784 S785 A836 Y838 G840 G841 G954 G957 F958 Y960 K1047 K1050 K1146 R1218
Binding residue
(residue number reindexed from 1)		F341 R440 R446 S447 A471 Y473 G475 G476 G580 G583 F584 Y586 K673 K676 K772 R844
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006260 DNA replication
GO:1902975 mitotic DNA replication initiation

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Molecular Function
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Biological Process
External links
PDB RCSB:8ucu, PDBe:8ucu, PDBj:8ucu
PDBsum8ucu
PubMed38491139
UniProtQ9DE46|DPOLA_XENLA DNA polymerase alpha catalytic subunit (Gene Name=pola1)

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