Structure of PDB 8uau Chain A Binding Site BS01

Receptor Information

>8uau Chain A (length=332) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

FYRCGYCKNESGSRSNGMWAHSMTVQDYQDLIDRGWRRSGKYVYKPVMNQ
TCCPQYTIRCRPLQFQPSKSHKKVLKKMLKFLAKGEVPKGSCEPPCRKAK
EIRKERKRLKLMQQNPAGELEGFQALFPPKAKSNQPKSLEDLIFESLPEN
ASHKLEVRLVPVSFEDPEFKSSFSQSFSLYVKYQVAIHQDPPDECGKTEF
TRFLCSSPLEAETPPNGPDCGYGSFHQQYWLDGKIIAVGVIDILPNCVSS
VYLYYDPDYSFLSLGVYSALREIAFTRQLHEKTSQLSYYYMGFYIHSCPK
MKYKGQYRPSDLLCPETYVWVPIEQCLPSLEN

Ligand information

>8uau Chain S (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

DDIAALVVDNGS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8uau Oligomerization and a distinct tRNA-binding loop are important regulators of human arginyl-transferase function.
Resolution	5.7 Å
Binding residue (original residue number in PDB)	Y21 Y25 Q299 E314 R317 F318 Y367 F408 I410
Binding residue (residue number reindexed from 1)	Y2 Y6 Q184 E199 R202 F203 Y252 F293 I295

External links

PDB	RCSB:8uau, PDBe:8uau, PDBj:8uau
PDBsum	8uau
PubMed	39068213
UniProt	O95260\|ATE1_HUMAN Arginyl-tRNA--protein transferase 1 (Gene Name=ATE1)

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