Structure of PDB 8u5y Chain A Binding Site BS01

Receptor Information
>8u5y Chain A (length=697) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RSWIQKVLEQIMDSPRQCVTPSEVVPVTVLAVQRYLLEDEPRDTVPKPPL
YCYDVTISDGVYQEKCYLDPSLNSLVYQNILKVGIQMRISRVSCLYNIGQ
GILCIDNVHCGETSDSISLETPFRNRAHQEKPERPLRGGKSHYLALWNNE
DPYGDIWLTDKQPEEHNFSDTKIISLSHLEMTWTNRRNFPALLVRILHKS
KLRYYGKPDKKMIEPYQTFLEVADSSGTVSVIMWNALCPEWYKSLRVGLV
LLLQDYSVKKSYPFRIQPVPVDPQIKLISTMEICLNLRDPPTNIIIIPEK
QVKPEWRLPKLNHRFTTRSELDDMPENCICDVIGLLVFVGRVQRSKKKEN
REDFWSYRWIHIADGTSEQPFIVELFSTSQPEIFENIYPMAYFVCTQLKV
VRNDNQVPKLLYLTTTNESGVFITGHRGQPYTYDAKVKNFIQWIRTKSDS
GEQKNMVIGGYYPYPPVPETFSKYSSSIKVESLLTAISEVRKEIEDLQYR
EQKRIAIQGIITAIKYIPHSSISDRWESQLWREKKFGLIDHLHYSRVYPE
SIPRKFMFEHRKFLSDQYNSQPAKYVPPEGRPPKLDDFKSARSLGHFEVT
ILGLNHEIAIDVAFLPMYCPEDIRTSQIDTLLTSMNYSCAYPQDTTGNDR
LPGPRAVAGDIIKAATELDRVHIVGILDICNLGNNKVEVYLHKIYSP
Ligand information
Receptor-Ligand Complex Structure
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PDB8u5y Structure of RADX and mechanism for regulation of RAD51 nucleofilaments
Resolution3.01 Å
Binding residue
(original residue number in PDB)		R248 Y250 K252 W279 K304 Y307 F309 N331 R333 K393 E394
Binding residue
(residue number reindexed from 1)		R203 Y205 K207 W234 K259 Y262 F264 N286 R288 K348 E349
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003697 single-stranded DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006282 regulation of DNA repair
GO:2000042 negative regulation of double-strand break repair via homologous recombination
Cellular Component
GO:0005657 replication fork
GO:0005694 chromosome
GO:0016607 nuclear speck

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8u5y, PDBe:8u5y, PDBj:8u5y
PDBsum8u5y
PubMed37786681
UniProtQ6NSI4|RADX_HUMAN RPA-related protein RADX (Gene Name=RADX)

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