Structure of PDB 8u5x Chain A Binding Site BS01

Receptor Information

>8u5x Chain A (length=569) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PSMSITRLFPALLECFGIVLCGYIAGRANVITSTQAKGLGNFVSRFALPA
LLFKNMVVLNFSNVDWSFLYSILIAKASVFFIVCVLTLLVASPDSRFSKA
GLFPIFATQSNDFALGYPIVEALYQTTYPEYLQYIYLVAPISLMMLNPIG
FIFCEIQKWKDTQNASQNKIKIVGLGLLRVLQNPIVFMVFIGIAFNFILD
RKVPVYVENFLDGLGNSFSGSALFYLGLTMVGKIKRLKKSAFVVLILLIT
AKLLVLPLLCREMVELLDKGDSVVNHTSLSNYAFLYGVFPVAPGVAIFAT
QFNMEVEIITSGMVISTFVSAPIMYVSAWLLTFPTMDPKPLAYAIQNVSF
DISIVSLISLIWSLAILLLSKKYKQLPHMLTTNLLIAQSIVCAGMMIWNF
VKEKNFVGQILVFVLLYSSLYSTYLWTGLLAISLFLLKKRERVQIPVGII
IISGWGIPALLVGVLLITGKHNGDSIDSAFFYGKEQMITTAVTLFCSILI
AGISLMCMNQQLTRHVLLCLLLIIGLFANLSSCLWWLFNQEPGRLYVELQ
FFCAVFNFGQGFISFGIFG

Ligand information

Ligand ID

IAC

InChI

InChI=1S/C10H9NO2/c12-10(13)5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6,11H,5H2,(H,12,13)

InChIKey

SEOVTRFCIGRIMH-UHFFFAOYSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.7.6	c1ccc2c(c1)c(c[nH]2)CC(=O)O
ACDLabs 12.01	O=C(O)Cc2c1ccccc1nc2
CACTVS 3.370	OC(=O)Cc1c[nH]c2ccccc12

Formula

C10 H9 N O2

Name

1H-INDOL-3-YLACETIC ACID;
INDOLE ACETIC ACID

PDB chain

8u5x Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8u5x Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1.
Resolution	2.79 Å
Binding residue (original residue number in PDB)	N145 F147 A148 A256 P327
Binding residue (residue number reindexed from 1)	N111 F113 A114 A222 P293
Annotation score	4

External links

PDB	RCSB:8u5x, PDBe:8u5x, PDBj:8u5x
PDBsum	8u5x
PubMed
UniProt	Q7Z3F1\|LYCHS_HUMAN Lysosomal cholesterol signaling protein (Gene Name=GPR155)

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