Structure of PDB 8u5g Chain A Binding Site BS01

Receptor Information
>8u5g Chain A (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLE
LEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETI
CLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTD
CFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDL
LWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDG
YEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
Ligand information
>8u5g Chain C (length=24) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PEKKVEWTSDTVDNEHMGRRSSKC
Receptor-Ligand Complex Structure
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PDB8u5g The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange
Resolution3.2 Å
Binding residue
(original residue number in PDB)		D166 K168 I169 D208 N219 R221 D242 Q249 V250 V251 E252 D253 Y255 E256 F257 A259 K260 R261 E287 L289 M290 C291 S292 F293
Binding residue
(residue number reindexed from 1)		D162 K164 I165 D204 N215 R217 D238 Q245 V246 V247 E248 D249 Y251 E252 F253 A255 K256 R257 E283 L285 M286 C287 S288 F289
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:8u5g, PDBe:8u5g, PDBj:8u5g
PDBsum8u5g
PubMed38042495
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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