Structure of PDB 8u36 Chain A Binding Site BS01

Receptor Information

>8u36 Chain A (length=424) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALRHENESVYKASLNLIEKYF

Ligand information

>8u36 Chain B (length=7) Species: 298331 (Frog siadenovirus A) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

RKRRRVA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8u36 Structural and functional characterization of nuclear localization signals of pVII protein of Frog siadenovirus
Resolution	2.6 Å
Binding residue (original residue number in PDB)	L104 S105 R106 P110 F138 W142 N146 A148 S149 G150 T155 Q181 W184 N188 D192 W231 R238
Binding residue (residue number reindexed from 1)	L33 S34 R35 P39 F67 W71 N75 A77 S78 G79 T84 Q110 W113 N117 D121 W160 R167

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8u36, PDBe:8u36, PDBj:8u36
PDBsum	8u36
PubMed
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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