Structure of PDB 8u15 Chain A Binding Site BS01

Receptor Information
>8u15 Chain A (length=352) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFA
VLAYREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDG
IQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPSYKWWQKYQKRKFH
CANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYR
VAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITT
KNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPG
YAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTKVIL
CL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8u15 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8u15 Structural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		C323 C391 C394
Binding residue
(residue number reindexed from 1)		C240 C308 C311
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:8u15, PDBe:8u15, PDBj:8u15
PDBsum8u15
PubMed38086859
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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