Structure of PDB 8u0t Chain A Binding Site BS01

Receptor Information
>8u0t Chain A (length=675) Species: 249024 (Rhinolophus alcyone) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPEDLAKIFLDNFNSEAENLSHQSSLASWEYNTNISDENIQKMDEAGAKW
SDFYETQSKHAKNFSLEEIHNDTVKLQLQILQQSGSPVLSEDKSKRLNSI
LNAMSTIYSTGKVCRPNNPQECLLLEPGLDNIMGTSKDYNERLWAWEGWR
AEVGKQLRPLYEEYVVLKNEMARGYHYEDYGDYWRRDYETEGSPDLEYSR
DQLTKDVERIFAEIKPLYEQLHAYVRTKLMDTYPFHISPTGCLPAHLLGD
MWGRFWTNLYPLTVPFAQKPNIDVTDAMLNQTWDAKRIFKEAEKFFVSIG
LPHMTEGFWNNSMLTDPGDGRKVVCHPTAWDLGKGDFRIKMCTKVTMEDF
LTAHHEMGHIQYDMAYASQPYLLRNGANEGFHEAVGEVMSLSVATPKHLK
TMGLLSPDFLEDNETEINFLFKQALTIVGTLPFTYMLEKWRWMVFKGEIP
KEEWMTKWWEMKRKIVGVVEPVPHDETYCDPASLFHVANDYSFIRYYTRT
IFEFQFHEALCRIAKHDGPLHKCDISNSTDAGKKLHQMLSVGKSQPWTSV
LKDFVDSKDMDVGPLLRYFEPLYTWLKEQNRNSFVGWNTDWSPYADQSIK
VRWNNNEMYLFRSSVAYAMREYFLKTKNQTILFGEEDVWVSNLKPRISFN
FYVTSPRNLSDIIPRPEVEGAIRMS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8u0t Chain A Residue 808 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8u0t Broad receptor tropism and immunogenicity of a clade 3 sarbecovirus.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H374 E402
Binding residue
(residue number reindexed from 1)		H355 E383
Annotation score1
Enzymatic activity
Enzyme Commision number 3.4.-.-
3.4.17.23: angiotensin-converting enzyme 2.
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8u0t, PDBe:8u0t, PDBj:8u0t
PDBsum8u0t
PubMed37989312
UniProtA0A0N7IQX6

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