Structure of PDB 8u0p Chain A Binding Site BS01

Receptor Information
>8u0p Chain A (length=322) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINAL
KSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLE
LFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLER
MPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPD
GRSHRGIFSRLLDSLRQEGFLTDDLVSQGKYLGVCRLPGPGRRHRRLDII
VVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVGRVLPT
PTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8u0p DNA polymerase lambda Loop1 variant yields unexpected gain-of-function capabilities in nonhomologous end-joining.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		W274 V462 Q464 K472 R514 R517 K521 L527 S528 E529 H530
Binding residue
(residue number reindexed from 1)		W38 V226 Q228 K230 R272 R275 K279 L285 S286 E287 H288
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8u0p, PDBe:8u0p, PDBj:8u0p
PDBsum8u0p
PubMed38428373
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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