Structure of PDB 8tvy Chain A Binding Site BS01

Receptor Information
>8tvy Chain A (length=1448) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAPLRTVKEVQFGLFSPEEVRAISVAKIRFPETMDETQTRAKIGGLNDPR
LGSIDRNLKCQTCQEGMNECPGHFGHIDLAKPVFHVGFIAKIKKVCECVC
MHCGKLLLDEHNELMRQALAIKDSKKRFAAIWTLCKTKMVCETDVPSEDD
PTQLVSRGGCGNTQPTIRKDGLKLVGSWKKDRATGDADEPELRVLSTEEI
LNIFKHISVKDFTSLGFNEVFSRPEWMILTCLPVPPPPVRPSISFNESQR
GEDDLTFKLADILKANISLETLEHNGAPHHAIEEAESLLQFHVATYMDND
IAGQPQALQKSGRPVKSIRARLKGKEGRIRGNLMGKRVDFSARTVISGDP
NLELDQVGVPKSIAKTLTYPEVVTPYNIDRLTQLVRNGPNEHPGAKYVIR
DSGDRIDLRYSKRAGDIQLQYGWKVERHIMDNDPVLFNRQPSLHKMSMMA
HRVKVIPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAELSQLCAV
PLQIVSPQSNKPCMGIVQDTLCGIRKLTLRDTFIELDQVLNMLYWVPDWD
GVIPTPAIIKPKPLWSGKQILSVAIPNGIHLQRFDEGTTLLSPKDNGMLI
IDGQIIFGVVEKKTVGSSNGGLIHVVTREKGPQVCAKLFGNIQKVVNFWL
LHNGFSTGIGDTIADGPTMREITETIAEAKKKVLDVTKEAQANLLTAKHG
MTLRESFEDNVVRFLNEARDKAGRLAEVNLKDLNNVKQMVMAGSKGSFIN
IAQMSACVGQQSVEGKRIAFGFVDRTLPHFSKDDYSPESKGFVENSYLRG
LTPQEFFFHAMGGREGLIDTAVKTAETGYIQRRLVKALEDIMVHYDNTTR
NSLGNVIQFIYGEDGMDAAHIEKQSLDTIGGSDAAFEKRYRVDLLNTDHT
LDPSLLESGSEILGDLKLQVLLDEEYKQLVKDRKFLREVFVDGEANWPLP
VNIRRIIQNAQQTFHIDHTKPSDLTIKDIVLGVKDLQENLLVLRGKNEII
QNAQRDAVTLFCCLLRSRLATRRVLQEYRLTKQAFDWVLSNIEAQFLRSV
VHPGEMVGVLAAQSIGEPATQMTLNTFHFAGVASKKVTSGVPRLKEILNV
AKNMKTPSLTVYLEPGHAADQEQAKLIRSAIEHTTLKSVTIASEIYYDPD
PRSTVIPEDEEIIQLHFSLLDEEAEQSFDQQSPWLLRLELDRAAMNDKDL
TMGQVGERIKQTFKNDLFVIWSEDNDEKLIIRCRVVRPKSLDAETEAEED
HMLKKIENTMLENITLRGVENIERVVMMKYDRKVPSPTGEYVKEPEWVLE
TDGVNLSEVMTVPGIDPTRIYTNSFIDIMEVLGIEAGRAALYKEVYNVIA
SDGSYVNYRHMALLVDVMTTQGGLTSVTRHGFNRSNTGALMRCSFEETVE
ILFEAGASAELDDCRGVSENVILGQMAPIGTGAFDVMIDEESLVKYMP
Ligand information
>8tvy Chain T (length=46) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgctctgctccttctccutcctctcgatggctatgagatcaactag
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tvy Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T44 Q45 K145 F252 Q256 E259 A309 K317 K332 R337 R344 Q447 Y836 E1403
Binding residue
(residue number reindexed from 1)		T37 Q38 K138 F245 Q249 E252 A302 K310 K325 R330 R337 Q440 Y829 E1396
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0006368 transcription elongation by RNA polymerase II
GO:0019985 translesion synthesis
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005665 RNA polymerase II, core complex
GO:0005739 mitochondrion
GO:0010494 cytoplasmic stress granule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tvy, PDBe:8tvy, PDBj:8tvy
PDBsum8tvy
PubMed38194460
UniProtP04050|RPB1_YEAST DNA-directed RNA polymerase II subunit RPB1 (Gene Name=RPO21)

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