Structure of PDB 8tof Chain A Binding Site BS01

Receptor Information
>8tof Chain A (length=545) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NEEVTFFEKAKRYIGNKHLYTEFLKILNLYSQDILDLDDLVEKVDFYLGS
NKELFTWFKNFVGYQGPSYKRLPKSDTFMPCSGRDDMCWEVLNDEWVGHP
VWASEDSGFIAHRKNQYEETLFKIEEERHEYDFYIESNLRTIQCLETIVN
KIENMTENEKANFKLPPGLGHTSMTIYKKVIRKVYDKERGFEIIDALHEH
PAVTAPVVLKRLKQKDEEWRRAQREWNKVWRELEQKVFFKSLDHLGLTFK
QADKKLLTTKQLISEISSIKVDQTNKKIHWLTPKPKSQLDFDFPDKNIFY
DILCLADTFITHTTAYSNPDKERLKDLLKYFISLFFSISFEKIEESLYSH
KQNVSESNRSIFNLFANTNIYIFFRHWTTIYERLLEIKQMNERVTKEINT
RSTVTFAKDLDLLSSQLSEMGLDFVGEDAYKQVLRLSRRLINGDLEHQWF
EESLRQAYNNKAFKLYTIDKVTQSLVKHAHTLMTDAKTAEIMALFVKDRN
ASTTSAKDQIIYRLQVRSHMSNTENMFRIEFDKRTLHVSIQYIAL
Ligand information
>8tof Chain N (length=176) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
tctgggtggtggccgttttcgttgtttttttctgtctcgtgccaggagac
tagggagtaatccccttggcggttaaaacgcgggggacagcgcgtacgtg
cgtttaagcggtgctagagctgtctacgaccaattgagcggcctcggcac
cgggattctgatatcgcgcgtgatct
Receptor-Ligand Complex Structure
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PDB8tof Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		Q937 K941
Binding residue
(residue number reindexed from 1)		Q251 K255
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006303 double-strand break repair via nonhomologous end joining
GO:0006325 chromatin organization
GO:0006334 nucleosome assembly
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0016479 negative regulation of transcription by RNA polymerase I
GO:0030174 regulation of DNA-templated DNA replication initiation
GO:0034605 cellular response to heat
GO:0044804 nucleophagy
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0061186 negative regulation of silent mating-type cassette heterochromatin formation
GO:0061188 negative regulation of rDNA heterochromatin formation
GO:0070550 rDNA chromatin condensation
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0032221 Rpd3S complex
GO:0033698 Rpd3L complex
GO:0070210 Rpd3L-Expanded complex
GO:0070822 Sin3-type complex

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tof, PDBe:8tof, PDBj:8tof
PDBsum8tof
PubMed38065958
UniProtP22579|SIN3_YEAST Transcriptional regulatory protein SIN3 (Gene Name=SIN3)

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