Structure of PDB 8tny Chain A Binding Site BS01

Receptor Information
>8tny Chain A (length=545) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HRILIERQEMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYFL
LGTSRHISVGIFGVLCLMIGETVDRELQKAGYICDKSCYAIMVGSTVTFI
AGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLNLP
RTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPIELVVVVAATL
ASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFA
ITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLV
KEQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDL
PKMWSISRMDTVIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKS
SLLGLVEESEVFESVSAYKNLQIKPGIKIFRFVAPLYYINKECFKSALYK
QTVNPILIKVAWKKAELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGI
QVLLAQCNPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKN
Ligand information
Ligand IDSO4
InChIInChI=1S/H2O4S/c1-5(2,3)4/h(H2,1,2,3,4)/p-2
InChIKeyQAOWNCQODCNURD-UHFFFAOYSA-L
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0[O-]S(=O)(=O)[O-]
CACTVS 3.341[O-][S]([O-])(=O)=O
ACDLabs 10.04[O-]S([O-])(=O)=O
FormulaO4 S
NameSULFATE ION
ChEMBL
DrugBankDB14546
ZINC
PDB chain8tny Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8tny Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2.
Resolution3.55 Å
Binding residue
(original residue number in PDB)		Y129 F165 A441
Binding residue
(residue number reindexed from 1)		Y26 F62 A296
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0019531 oxalate transmembrane transporter activity
Biological Process
GO:0001503 ossification
GO:0002062 chondrocyte differentiation
GO:0015701 bicarbonate transport
GO:0019532 oxalate transport
GO:0035988 chondrocyte proliferation
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031528 microvillus membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tny, PDBe:8tny, PDBj:8tny
PDBsum8tny
PubMed38684689
UniProtP50443|S26A2_HUMAN Sulfate transporter (Gene Name=SLC26A2)

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