Structure of PDB 8tlx Chain A Binding Site BS01

Receptor Information

>8tlx Chain A (length=439) Species: 9606,83333

SKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPCMSAFWYAVRTAVIN
AASGRQTVDEALKDAQTAAADKCYLDELVELHRRLMTLRERHILQQIVNL
IEETGHFHITNTTFDFDLCSLDKTTVRKLQSYLETSGTS

Ligand information

>8tlx Chain B (length=7) Species: 32630 (synthetic construct)

LPVAAPL

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8tlx Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors.
• Resolution: 2.097 Å
• Binding residue (original residue number in PDB): H382 M386 L394 I409 T412 T413 F414 D415 F416 D417
• Binding residue (residue number reindexed from 1): H382 M386 L394 I409 T412 T413 F414 D415 F416 D417

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:1901982 maltose binding

Biological Process

• GO:0006974 DNA damage response
• GO:0008643 carbohydrate transport
• GO:0015768 maltose transport
• GO:0034219 carbohydrate transmembrane transport
• GO:0034289 detection of maltose stimulus
• GO:0042956 maltodextrin transmembrane transport
• GO:0060326 cell chemotaxis

Cellular Component

• GO:0016020 membrane
• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space
• GO:0043190 ATP-binding cassette (ABC) transporter complex
• GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
• GO:1990060 maltose transport complex

External links

• PDB: RCSB:8tlx, PDBe:8tlx, PDBj:8tlx
• PDBsum: 8tlx
• PubMed: 38747396
• UniProt: P0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
  P42568|AF9_HUMAN Protein AF-9 (Gene Name=MLLT3)