Structure of PDB 8tlv Chain A Binding Site BS01

Receptor Information
>8tlv Chain A (length=433) Species: 9606,83333 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQV
AATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYN
GKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFN
LQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIK
NKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTF
KGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLG
AVALKSYEEELAKDPRIAATMENAQKGEIMPNIPCMSAFWYAVRTAVINA
ASGRQTVDEALKDAQTAAAADCAYLDELVELHRRLMTLRERHILQQIVNL
IEETGHFHITNTTFDFDLCSLDKTTVRKLQSYL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tlv Structural studies of intrinsically disordered MLL-fusion protein AF9 in complex with peptidomimetic inhibitors.
Resolution2.659 Å
Binding residue
(original residue number in PDB)		S74 L379 H383 L395 Q396 N412 T413 T414 F415 D416 F417 D418 L419 C420
Binding residue
(residue number reindexed from 1)		S73 L378 H382 L394 Q395 N411 T412 T413 F414 D415 F416 D417 L418 C419
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:1901982 maltose binding
Biological Process
GO:0006974 DNA damage response
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0034219 carbohydrate transmembrane transport
GO:0034289 detection of maltose stimulus
GO:0042956 maltodextrin transmembrane transport
GO:0060326 cell chemotaxis
Cellular Component
GO:0016020 membrane
GO:0030288 outer membrane-bounded periplasmic space
GO:0042597 periplasmic space
GO:0043190 ATP-binding cassette (ABC) transporter complex
GO:0055052 ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060 maltose transport complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tlv, PDBe:8tlv, PDBj:8tlv
PDBsum8tlv
PubMed38747396
UniProtP0AEX9|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE);
P42568|AF9_HUMAN Protein AF-9 (Gene Name=MLLT3)

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