Structure of PDB 8tlt Chain A Binding Site BS01

Receptor Information
>8tlt Chain A (length=1272) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SDYFRIQLNNQDYYMSKPTFLDPSHGESLPLNQFSQVPNIRVFGALPTGH
QVLCHVHGILPYMFIKYDGQITDTSTLRHQRCAQVHKTLEVKIRASFKKL
GNLNFVADVSVVKGIPFYGYHVGWNLFYKISLLNPSCLSRISELIRDGKI
FGKKFEIYESHIPYLLQWTADFNLFGCSWINVDRCYFRSPVLNSILDIDK
LTINDDLQLLLDRFCDFKCNVLSRRDFPRVGNGLIEIDILPQFIKNREKL
QHRDIHHDFLEKLGDIKPYVSSARDMINELTMQREELSLKEYKEPPETKR
HVHQWQSSGEFEAFYKKAQHKTSTFDGQIPNFENFIDKNQKFSAINTPYE
ALPQLWPRLPGLRYGKRAFVYGEPPFGYQDILNKLEDEGFPKIDYKDPFF
SNPVDLENKPYAYAGKRFEISSTHVSTRIPVQFGGETVSVYNKPTFDMFS
SWKYALKPPTYDAVQKWYNKVSSVHDSLTHLTLEIHANTRSDKIPDPAID
EVSMIIWCLEEETFPLDLDIAYEGIMIVHKASEDSTFPTKIQHCINEIPV
MFYESEFEMFEALTDLVLLLDPDILSGFEIHNFSWGYIIERCQKIHQFDI
VRELARVKCQIKLSDTWGYAHSSGIMITGRHMINIWRALRSDVNLTQYTI
ESAAFNILHKRLPHFSFESLTNMWNAKKSTTELKTVLNYWLSRAQINIQL
LRKQDYIARNIEQARLIGIDFHSVYYRGSQFKVESFLIRICKSESFILLS
PGKKDVRKQKALECVPLVMEPESAFYKSPLIVLDFQSLYPSIMIGYNYCY
STMIGRVREINLTENNLGVSKFSLPRNILALLKNDVTIAPNGVVYAKTSV
RKSTLSKMLTDILDVRVMIKKTMNEIGDDNTTLKRLLNNKQLALKLLANV
TYGYTSASFSGRMPCSDLADSIVQTGRETLEKAIDIIEKDETWNAKVVYG
DTDSLFVYLPGKTAIEAFSIGHAMAERVTQNNPKPIFLKFEKVYHPSILI
SKKRYVGFSYESPSQTLPIFDAKGIETVRRDGIPAQQKIIEKCIRLLFQT
KDLSKIKKYLQNEFFKIQIGKVSAQDFCFAKEVKLGAYKSEKTAPAGAVV
VKRRINEDHRAEPQYKERIPYLVVKGKQGQLLRERCVSPEEFLEGENLEL
DSEYYINKILIPPLDRLFNLIGINVGNWAQEIDDCLEKRSTTTLSFLIKK
LKRQKEYQTLKTVCRTCSYRYTSDAGIENDHIASKCNSYDCPVFYSRVKA
ERYLRDNQSVQREEALISLNDW
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tlt Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
Resolution2.85 Å
Binding residue
(original residue number in PDB)		K1194 Y1196 G1215 R1220 K1272 E1273 Y1279 K1280 R1309
Binding residue
(residue number reindexed from 1)		K1003 Y1005 G1024 R1029 K1081 E1082 Y1088 K1089 R1118
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0006260 DNA replication
GO:0006281 DNA repair
GO:0006974 DNA damage response
GO:0019985 translesion synthesis
GO:0042276 error-prone translesion synthesis
GO:0070987 error-free translesion synthesis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0016035 zeta DNA polymerase complex
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8tlt, PDBe:8tlt, PDBj:8tlt
PDBsum8tlt
PubMed38720088
UniProtP14284|DPOZ_YEAST DNA polymerase zeta catalytic subunit (Gene Name=REV3)

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