Structure of PDB 8th9 Chain A Binding Site BS01

Receptor Information
>8th9 Chain A (length=253) Species: 13616 (Monodelphis domestica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PEGPSLRKFHQLVAPFVGQLVVTVGGNSKKINPNMLEMLRLQDSQVHGKN
LYLNFGLTSGLWLCFHFGLFGSVRASELSRATKANKRWKDPIPRLVLHFA
KGFLAFYNCRIYWCLGPTVKPTSDILSEEFDRRQALEALKQASPVSYTLL
DQRYFAGLGNIIKNEVLYLARIHPLSLGSCLTPLNLESLLDHVVSFSVGW
LQKKLEGKPLHHLIYQKEQCPAGHQVMKDSFGPPGSFQRLTWWCPHCQPK
AEE
Ligand information
Receptor-Ligand Complex Structure
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PDB8th9 Structural and biochemical insights into NEIL2's preference for abasic sites
Resolution2.08 Å
Binding residue
(original residue number in PDB)		F142 A153 T154 K155 N157 P165 L284 H285 H286 K291
Binding residue
(residue number reindexed from 1)		F70 A81 T82 K83 N85 P91 L210 H211 H212 K217
Enzymatic activity
Enzyme Commision number 4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003684 damaged DNA binding
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0008270 zinc ion binding
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:8th9, PDBe:8th9, PDBj:8th9
PDBsum8th9
PubMed37971311
UniProtF7AMK3

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