Structure of PDB 8th4 Chain A Binding Site BS01

Receptor Information
>8th4 Chain A (length=382) Species: 562,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNL
ALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENT
NITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKA
YDLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPMKDFR
HGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARST
LDKLNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIV
DTAMPITICIAYFNNCLNPLFYGFLGKKFKRY
Ligand information
Ligand IDLSN
InChIInChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
InChIKeyPSIFNNKUMBGKDQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.6CCCCc1nc(c(n1Cc2ccc(cc2)c3ccccc3c4n[nH]nn4)CO)Cl
CACTVS 3.385CCCCc1nc(Cl)c(CO)n1Cc2ccc(cc2)c3ccccc3c4n[nH]nn4
FormulaC22 H23 Cl N6 O
Name[2-butyl-5-chloranyl-3-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol;
Losartan
ChEMBLCHEMBL191
DrugBankDB00678
ZINCZINC000003873160
PDB chain8th4 Chain A Residue 1401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8th4 Antibodies expand the scope of angiotensin receptor pharmacology
Resolution3.3 Å
Binding residue
(original residue number in PDB)		Y35 W84 S105 V108 S109 L112 A163 R167 F182 Y1292
Binding residue
(residue number reindexed from 1)		Y15 W64 S85 V88 S89 L92 A138 R142 F157 Y362
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0046872 metal ion binding
Cellular Component
GO:0042597 periplasmic space

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Molecular Function
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Cellular Component
External links
PDB RCSB:8th4, PDBe:8th4, PDBj:8th4
PDBsum8th4
PubMed38744986
UniProtP0ABE7|C562_ECOLX Soluble cytochrome b562 (Gene Name=cybC);
P30556

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