Structure of PDB 8th1 Chain A Binding Site BS01

Receptor Information
>8th1 Chain A (length=137) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKP
ADAVYGQKEIHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNN
NQALRRFMQTFVLAPEGVANKFYVHNDIFRYQDEVFG
Ligand information
>8th1 Chain E (length=7) Species: 2697049 (Severe acute respiratory syndrome coronavirus 2) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
RITFGGP
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8th1 Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		F15 Q18 R32 F33 N122 K123 F124 Y125
Binding residue
(residue number reindexed from 1)		F14 Q17 R31 F32 N120 K121 F122 Y123
Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
External links
PDB RCSB:8th1, PDBe:8th1, PDBj:8th1
PDBsum8th1
PubMed38492217
UniProtQ13283|G3BP1_HUMAN Ras GTPase-activating protein-binding protein 1 (Gene Name=G3BP1)

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