Structure of PDB 8tg9 Chain A Binding Site BS01

Receptor Information
>8tg9 Chain A (length=426) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVL
GSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHW
RVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQA
LMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLL
RTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQG
GQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHL
AYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQ
RMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQE
LVAVSGRKLNWPLGYPPPDIPKCGFD
Ligand information
>8tg9 Chain C (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
CFGGRMDRIGAQSGLGCNSFR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tg9 Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Resolution3.08 Å
Binding residue
(original residue number in PDB)		Y88 Y154 F165 V168 E169 F172 M173 H185
Binding residue
(residue number reindexed from 1)		Y88 Y154 F165 V168 E169 F172 M173 H185
External links
PDB RCSB:8tg9, PDBe:8tg9, PDBj:8tg9
PDBsum8tg9
PubMed
UniProtP16066|ANPRA_HUMAN Atrial natriuretic peptide receptor 1 (Gene Name=NPR1)

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