Structure of PDB 8teb Chain A Binding Site BS01

Receptor Information

>8teb Chain A (length=306) Species: 29291 (Methanococcoides burtonii)

MITCSAPGKVYLFGEHAVVYGEPAICCAVDIRTRVTVSPADTITISSSLG
TTGIDFEVHPYVSAVLERFQDISSFDGVDLRISSDIPVGSGLGSSAAVTV
ATIKAMDTLLDLGLELDDIAKMGHEVEQNIQGTASPTDTYVCTMGGVVLI
PQRKKLELIDCGILIGNTNIFSSTKELVGNVADLNERFPDVVGPVLSSIG
KLSVIGEGLVNDRDYVSVGELMNIDQGLLDAIGVSCAELSSLIYAARESG
AYGSKITGAGGGGCMVAISPRENVDSVAEAIGMAGGKVVVANATDIGVRV
ECQLVP

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 8teb Chain A Residue 403

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8teb Characterization of novel mevalonate kinases from the tardigrade Ramazzottius varieornatus and the psychrophilic archaeon Methanococcoides burtonii.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): A96 E127 D138
• Binding residue (residue number reindexed from 1): A96 E127 D138
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.1.36: mevalonate kinase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004335 galactokinase activity
• GO:0004496 mevalonate kinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006012 galactose metabolic process
• GO:0008299 isoprenoid biosynthetic process
• GO:0016310 phosphorylation
• GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway
• GO:0046835 carbohydrate phosphorylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:8teb, PDBe:8teb, PDBj:8teb
• PDBsum: 8teb
• PubMed: 38411551
• UniProt: Q12TI0