Structure of PDB 8tc1 Chain A Binding Site BS01

Receptor Information
>8tc1 Chain A (length=1088) Species: 285945 (Civet SARS CoV 007/2004) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDRCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSN
VTGFHTINHTFDNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVI
IINNSTNVVIRACNFELCDNPFFVVSKPMGTQTHTMIFDNAFNCTFEYIS
DAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNT
LKPIFKLPLGIKITNFRAILTAFSPAQGTWGTSAAAYFVGYLKPTTFMLK
YDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVR
FPNITNLCPFGEVFNATKFPSVYAWERKRISNCVADYSVLYNSTSFSTFK
CYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDD
FMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSSDGK
PCTPPAPNCYWPLRGYGFYTTSGIGYQPYRVVVLSFELLNAPATVCGPKL
STDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDP
KTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTLAWRIYS
TGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTVQKSIVAYTMS
LGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTE
CANLLLQYGSFCRQLNRALSGIAAEQDRNTREVFVQVKQMYKTPTLKDFG
GFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARD
LICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPF
AMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKL
QDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLIT
GRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYH
LMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFS
SWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVY
Ligand information
Ligand IDEIC
InChIInChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6-,10-9-
InChIKeyOYHQOLUKZRVURQ-HZJYTTRNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CCCCCC=CCC=CCCCCCCCC(O)=O
CACTVS 3.341CCCCC/C=C\C\C=C/CCCCCCCC(O)=O
OpenEye OEToolkits 1.5.0CCCCC\C=C/C\C=C/CCCCCCCC(=O)O
OpenEye OEToolkits 1.5.0CCCCCC=CCC=CCCCCCCCC(=O)O
ACDLabs 10.04O=C(O)CCCCCCC\C=C/C\C=C/CCCCC
FormulaC18 H32 O2
NameLINOLEIC ACID;
9,12-LINOLEIC ACID
ChEMBLCHEMBL267476
DrugBankDB14104
ZINCZINC000004474613
PDB chain8tc1 Chain B Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8tc1 Cryo-EM reveals variationo in structural motifs within animal SARS-related coronavirus spike protein
Resolution1.92 Å
Binding residue
(original residue number in PDB)		P311 F312 F366
Binding residue
(residue number reindexed from 1)		P309 F310 F364
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0039654 fusion of virus membrane with host endosome membrane
GO:0046813 receptor-mediated virion attachment to host cell
GO:0075509 endocytosis involved in viral entry into host cell
Cellular Component
GO:0016020 membrane
GO:0019031 viral envelope
GO:0055036 virion membrane

View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8tc1, PDBe:8tc1, PDBj:8tc1
PDBsum8tc1
PubMed38805567
UniProtQ3ZTF3

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