Structure of PDB 8tah Chain A Binding Site BS01

Receptor Information

>8tah Chain A (length=403) Species: 9913 (Bos taurus)

GRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKEKGVDDLDFFIGDE
AIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEP
PLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTG
TVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGI
PPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKK
EFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPL
YKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDV
QVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFG
VMS

Ligand information

>8tah Chain H (length=10) Species: 10090 (Mus musculus)

DDWETDPDFV

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8tah Mechanism of Synergistic Activation of Arp2/3 Complex by Cortactin and WASP-Family Proteins
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): R230 Y231 Y233 P236 K251 W252 K254 R329 D330 R333 R334
• Binding residue (residue number reindexed from 1): R215 Y216 Y218 P221 K236 W237 K239 R314 D315 R318 R319

Gene Ontology

Molecular Function

• GO:0003779 actin binding
• GO:0005515 protein binding
• GO:0005524 ATP binding
• GO:0051015 actin filament binding

Biological Process

• GO:0010592 positive regulation of lamellipodium assembly
• GO:0030030 cell projection organization
• GO:0034314 Arp2/3 complex-mediated actin nucleation
• GO:0045944 positive regulation of transcription by RNA polymerase II
• GO:0060271 cilium assembly

Cellular Component

• GO:0005634 nucleus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0005885 Arp2/3 protein complex
• GO:0035861 site of double-strand break
• GO:0042995 cell projection

External links

• PDB: RCSB:8tah, PDBe:8tah, PDBj:8tah
• PDBsum: 8tah
• PubMed: 37898612
• UniProt: P61157|ARP3_BOVIN Actin-related protein 3 (Gene Name=ACTR3)