Structure of PDB 8t8s Chain A Binding Site BS01

Receptor Information

>8t8s Chain A (length=636) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLV
IMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLT
AEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALST
ENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALE
LWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGD
TWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIV
YSKSLDRHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGG
RWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAV
GIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIV
AIEHSSRPINVIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISI
WGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCI
LGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPESK
CVEQPLKGHDLEFCLYLTTNGYRKIPGDKCQGGVNP

Ligand information

>8t8s Chain C (length=16) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

PRWDAPLRDPALRQLL

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8t8s Structural studies of Sortilin-PGRN peptide complex
Resolution	2.99 Å
Binding residue (original residue number in PDB)	L75 S78 V79 S80 L81 K227 F273 G274 L275 S283 R292 Y318 S319 I320 L321 Y362 T537 G538 W553 W564
Binding residue (residue number reindexed from 1)	L23 S26 V27 S28 L29 K175 F221 G222 L223 S231 R240 Y266 S267 I268 L269 Y310 T485 G486 W501 W512

External links

PDB	RCSB:8t8s, PDBe:8t8s, PDBj:8t8s
PDBsum	8t8s
PubMed
UniProt	Q99523\|SORT_HUMAN Sortilin (Gene Name=SORT1)

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