Structure of PDB 8t8r Chain A Binding Site BS01

Receptor Information

>8t8r Chain A (length=651) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CGRVRDFVAKLANNTHQHVFDDLSVSLSWVGDSTGVILVLTTFHGQSKLY
RSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGG
RIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNF
GGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKS
FKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTDQGDTWSMAQLPSV
GQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLY
TTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPEN
SECDATAKNKNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVG
DAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPIN
VIKFSTDEGQCWQTYTFTRDPIYFTGLASEPGARSMNISIWGFTESTSQW
VSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKEQFLRLRK
SSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGH
DLEFCLYGREEHLTTNGYRKIPGDKCQGGVNPVREVKDLKKKCTSNFLSP
E

Ligand information

>8t8r Chain B (length=11) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

WDAPLALRPIL

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	8t8r Structural studies of Sortilin-PGRN peptide complex
Resolution	2.87 Å
Binding residue (original residue number in PDB)	V79 L81 Y271 F273 S283 R292 Y318 I320 L321 F371 T537 W553 W564
Binding residue (residue number reindexed from 1)	V25 L27 Y209 F211 S221 R230 Y256 I258 L259 F309 T475 W491 W500

External links

PDB	RCSB:8t8r, PDBe:8t8r, PDBj:8t8r
PDBsum	8t8r
PubMed
UniProt	Q99523\|SORT_HUMAN Sortilin (Gene Name=SORT1)

[Back to BioLiP]