Structure of PDB 8t7s Chain A Binding Site BS01 |
| >8t7s Chain A (length=1312) Species: 1314 (Streptococcus pyogenes)
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KKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALL
FDSGETAERTRLKRTARRRYTRRKNRICYLQEIFSNEMAKVDDSFFHRLE
ESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLR
LIYLALAHMIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLAKAILSA
RLSKSRRLENLIAQKNGLFGNLIALSLGLTPNFKSNFDLAEDAKLQLSKD
TYDDDLDNLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDL
TLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEK
MDGTEELLVKLNREDLLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPF
LKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVV
DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTE
GMRKPAFLSGEQKKAIVDLLFKTNRKVTVKQLKEDYFKKIECFDSVEISG
VEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMI
EERLKTYAHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDF
LKSDGFANRNFMQLIHDDSLTFKEDIQKAQDSLHEHIANLAGSPAIKKGI
LQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEG
IKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYD
VDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMKNYWRQLL
NAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDS
RMNTKYDENDKLIREVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDA
YLNAVVGTALIKKYPKLESEFVYGIGKATAKYFFYSNIMNFFKTEITLAN
GEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGG
FSKESIRPKRNSDKLIARKKDWDPKKYGGFLWPTVAYSVLVVAKVEKGKS
KKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPKYSLF
ELENGRKRMLASAKQLQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQ
KQLFVEQHKHYLDEIIEQISEFSKRVILADANLDKVLSAYNKHRDKPIRE
QAENIIHLFTLTRLGAPRAFKYFDTTIDPKQYRSTKEVLDATLIHQSITG
LYETRIDLSQLG |
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| PDB | 8t7s Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9 |
| Resolution | 3.01 Å |
Binding residue
(original residue number in PDB) | K30 K33 R40 I43 K44 N46 G56 E57 T58 A59 R61 T62 R63 K65 R66 R69 R70 R71 Y72 R74 R75 K76 N77 L101 S104 F105 L106 E108 K111 R115 H116 P117 I122 V126 H129 H160 K163 F164 R165 G166 Y325 H328 K336 R340 F351 F352 Y359 A360 I363 Q402 R403 T404 F405 N407 G408 F446 R447 I448 Y450 G453 P454 L455 A456 R457 N459 S460 F462 W464 R467 T472 I473 Y515 F518 T519 N588 R661 L662 M694 S719 H721 E722 S730 P731 K735 L738 K742 K749 R753 S777 R778 E779 R780 N803 Y812 K848 D849 D850 S851 I852 K918 R919 Y981 S1006 Y1010 P1090 Q1091 E1099 V1100 T1102 G1103 G1104 F1105 I1110 P1112 K1113 R1122 K1123 K1124 K1130 Y1131 F1134 E1225 L1226 A1227 P1229 Q1272 H1349 Q1350 S1351 Y1356 |
Binding residue
(residue number reindexed from 1) | K28 K31 R38 I41 K42 N44 G54 E55 T56 A57 R59 T60 R61 K63 R64 R67 R68 R69 Y70 R72 R73 K74 N75 L99 S102 F103 L104 E106 K109 R113 H114 P115 I120 V124 H127 H158 K161 F162 R163 G164 Y293 H296 K304 R308 F319 F320 Y327 A328 I331 Q370 R371 T372 F373 N375 G376 F414 R415 I416 Y418 G421 P422 L423 A424 R425 N427 S428 F430 W432 R435 T440 I441 Y483 F486 T487 N556 R629 L630 M662 S682 H684 E685 S693 P694 K698 L701 K705 K712 R716 S740 R741 E742 R743 N766 Y775 K811 D812 D813 S814 I815 K881 R882 Y944 S969 Y973 P1036 Q1037 E1045 V1046 T1048 G1049 G1050 F1051 I1056 P1058 K1059 R1068 K1069 K1070 K1076 Y1077 F1080 E1171 L1172 A1173 P1175 Q1218 H1295 Q1296 S1297 Y1302 |
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