Structure of PDB 8t7c Chain A Binding Site BS01

Receptor Information
>8t7c Chain A (length=1001) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADKIEGFLD
IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSK
EDAVNWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLREL
KTILPLINFKVSSAKFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKS
ILDEFGSGSAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRET
AEPFLFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTY
LTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKI
KFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEVFGDLLL
TKPTEASADQLPSPSQLREKIIIKHKKLGPHKQQGELYMWDSIDQKWTRH
YCAIADAKLSFSDDIEPNPHESKPWYYDSLSRGEAEDMLMRIPRDGAFLI
RKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYYE
KHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQ
RTVKALYDYKAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPS
NYVEDISTADFEELEKQIIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKS
FVFILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKQSIAIELSDLVV
YCKPTSKTNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYP
KGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYV
LQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSIACPFVEV
EICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVY
EEDMFSDPNFLAHATYPIKAVKSGFRSVPLKNGYSEDIELASLLVFCEMR
P
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8t7c Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8t7c The crystal and cryo-EM structures of PLCg2 reveal dynamic inter-domain recognitions in autoinhibition
Resolution2.55 Å
Binding residue
(original residue number in PDB)		N328 E357 D359 E406
Binding residue
(residue number reindexed from 1)		N298 E327 D329 E376
Annotation score1
External links
PDB RCSB:8t7c, PDBe:8t7c, PDBj:8t7c
PDBsum8t7c
PubMed
UniProtP16885|PLCG2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (Gene Name=PLCG2)

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