Structure of PDB 8t70 Chain A Binding Site BS01

Receptor Information
>8t70 Chain A (length=318) Species: 5207 (Cryptococcus neoformans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYIPMSQRRSWADVKPIMQDDGPNPVVPIMYSEEYKDAMDYFRAIAAKEE
KSERALELTEIIVRMNPAHYTVWQYRFSLLTSLNKSLEDELRLMNEFAVQ
NLKSYQVWHHRLLLLDRISPQDPVSEIEYIHGSLLPDPKNYHTWAYLHWL
YSHFSTLGRISEAQWGSELDWCNEMLRVDGRNNSAWGWRWYLRVSRPGAE
TSSRSLQDELIYILKSIHLIPHNVSAWNYLRGFLKHFSLPLVPILPAILP
YTAFGFPMPSDPLPEDTPLPVPLALEYLADSFIEQNRVDDAAKVFEKLSS
EYDQMRAGYWEFRRRECA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8t70 Cryptococcus neoformans protein farnesyltransferase in complex with FPTII and TKCMIIM peptide
Resolution1.892 Å
Binding residue
(original residue number in PDB)		Y74 Y109 Q110
Binding residue
(residue number reindexed from 1)		Y70 Y105 Q106
Enzymatic activity
Enzyme Commision number 2.5.1.58: protein farnesyltransferase.
2.5.1.59: protein geranylgeranyltransferase type I.
Gene Ontology
Molecular Function
GO:0004659 prenyltransferase activity
GO:0004660 protein farnesyltransferase activity
GO:0004662 CAAX-protein geranylgeranyltransferase activity
GO:0008318 protein prenyltransferase activity
Biological Process
GO:0018342 protein prenylation
GO:0018343 protein farnesylation
GO:0018344 protein geranylgeranylation
Cellular Component
GO:0005737 cytoplasm
GO:0005953 CAAX-protein geranylgeranyltransferase complex
GO:0005965 protein farnesyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t70, PDBe:8t70, PDBj:8t70
PDBsum8t70
PubMed
UniProtJ9VSJ6

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