Structure of PDB 8t5s Chain A Binding Site BS01

Receptor Information
>8t5s Chain A (length=693) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLCLRNYQEELCQVALQGKNTIVTAPTGSGKTVIAANIIKEHFESRSSEG
KRFKALFMTPNSMILNQQAASISSYLDHVYHTQIIQGSDNVPTRNVIQSK
DLIVATPQMIVNLCNEHRNSLDSRLDQFFLSTFTIIFFDECHNTVKNSPY
SNIMREYHYLKNMGNMPEGHSLPQIIGLTASLGTGDKNDCLQVRNYIAGL
CASMDVKDLSIVKDNLEELRGYSPIVPDKVLLCERSTDGPIGMFTNRLTL
MMQEVEGLIRTALRNEHIGSFLDPPADKEHAGYQNWVCNQMNLVSGTSFR
ETGTRTIINEALDVLKECFCTLSYNINFHPEVALNYLKDEMEYRTPNFTV
NMIRIWERYHNQLVGTGSAENPMISKTVQYIVEQNLQRADSRTIIFVRTR
YEATILNKVLNSNEELLMLGIKSEWMSGLNKSTASSADISASKQKQMEKL
KMFADGEIRILVSTSVAEEGLDVPECSLVIKYNYATNEIAHVQRRGRGRA
LNSECVLITNSIALRDQESNNRDKESLMSETISLIQNSPAEFRKCVDEES
NKIWPRILREDTDKAQKIEEQINRNIVYKIICKKCEAILCTSKDIRSRNT
QYLVCDPGFWSLVRKTRTGSINCRRENCGLKLGQLIEVNTVDLPCLSALS
IVLLVEGTDKRIIVKKWKNILDKYFTPTEIRQLDVQTMRDADQ
Ligand information
>8t5s Chain C (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
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Receptor-Ligand Complex Structure
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PDB8t5s C. elegans Dicer acts with the RIG-I-like helicase DRH-1 and RDE-4 to cleave dsRNA
Resolution2.9 Å
Binding residue
(original residue number in PDB)		K437 N438 A590 G591 N594 Q753 T795 N796 Q826 T909 Q910 Q956 K988 W989 K990
Binding residue
(residue number reindexed from 1)		K146 N147 A281 G282 N285 Q444 T486 N487 Q517 T600 Q601 Q634 K666 W667 K668
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t5s, PDBe:8t5s, PDBj:8t5s
PDBsum8t5s
PubMed38747717
UniProtG5EDI8

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