Structure of PDB 8t57 Chain A Binding Site BS01

Receptor Information
>8t57 Chain A (length=504) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLSALLTSVGINLGLCFLFFTLYSIWVKRALEPTNDEILSNLGLDALVFI
RVFVFSIRVFSFASVVGIFILLPVNYKSMDNFSISNVNDGSNKLWIHFCA
IYIFTAVVCSLLYYEHKYILTKRIAHLYSSKPQPQEFTVLVSGVPLVSGN
SISETVENFFREYHSSSYLSHIVPAAFVSFRTRHGAAIATNIQQGIDPTQ
WLTEAAPEPEDVHWPFFTASFVRRWISNVVVLVAFVALLILPSLIFQLFL
LIVPPIMLLLSSMQGFISHSQIEKSACIKLLIFTVWNSFFANVLSGSALY
RVNVFLEPKTIPRVLAAAVPAQASFFVSYVVTSGWTGLSSEILRLVPLVP
STPFCQEIPRILFFGLLGITYFFLSPLILPFLLVYYCLGYIIYRNQLLNV
YAAKYETGGKFWPIVHSYTIFSLVLMHIIAVGLFGLKELPVASSLTIPLP
VLTVLFSIYCQRRFLPNFKSYPTQCLVNKDKADEREQNMSEFYSELVVAY
RDPA
Ligand information
Ligand IDCLR
InChIInChI=1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChIKeyHVYWMOMLDIMFJA-DPAQBDIFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
CACTVS 3.341CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
ACDLabs 10.04OC4CCC3(C(=CCC2C1C(C(C(C)CCCC(C)C)CC1)(C)CCC23)C4)C
OpenEye OEToolkits 1.5.0CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)O)C)C
CACTVS 3.341CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](O)CC[C]4(C)[CH]3CC[C]12C
FormulaC27 H46 O
NameCHOLESTEROL
ChEMBLCHEMBL112570
DrugBankDB04540
ZINCZINC000003875383
PDB chain8t57 Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8t57 Structure of mechanically activated ion channel OSCA2.3 reveals mobile elements in the transmembrane domain.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		I447 W455 F459 F474 F608
Binding residue
(residue number reindexed from 1)		I278 W286 F290 F305 F421
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0008381 mechanosensitive monoatomic ion channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t57, PDBe:8t57, PDBj:8t57
PDBsum8t57
PubMed38103547
UniProtQ8GUH7|CSCLC_ARATH CSC1-like protein HYP1 (Gene Name=HYP1)

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