Structure of PDB 8t4m Chain A Binding Site BS01

Receptor Information

>8t4m Chain A (length=533) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRF
YWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVCLLDLIMN
FRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGR
ALRIVRFTKILCLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLI
GMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKA
MSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDS
SRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNE
LNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYI
IREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTAS
VRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILL
QKFQKDLNTGVFNNQENEILKQIVKHDREMVQA

Ligand information

Ligand ID

CMP

InChI

InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1

InChIKey

IVOMOUWHDPKRLL-KQYNXXCUSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04	O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341	Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341	Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O

Formula

C10 H12 N5 O6 P

Name

ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP

PDB chain

8t4m Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8t4m Structural Basis for Hyperpolarization-dependent Opening of the Human HCN1 Channel
Resolution	3.16 Å
Binding residue (original residue number in PDB)	M530 F538 G539 I541 R549 T550 A551 R590 I594 V633
Binding residue (residue number reindexed from 1)	M428 F436 G437 I439 R447 T448 A449 R488 I492 V531
Annotation score	1

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005222	intracellularly cAMP-activated cation channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005267	potassium channel activity
GO:0005272	sodium channel activity
GO:0005515	protein binding
GO:0022843	voltage-gated monoatomic cation channel activity
GO:0030552	cAMP binding
GO:0042802	identical protein binding
GO:0140232	intracellular cAMP-activated cation channel activity involved in regulation of presynaptic membrane potential

	Biological Process
GO:0003254	regulation of membrane depolarization
GO:0006814	sodium ion transport
GO:0019228	neuronal action potential
GO:0035725	sodium ion transmembrane transport
GO:0042391	regulation of membrane potential
GO:0045176	apical protein localization
GO:0046549	retinal cone cell development
GO:0051289	protein homotetramerization
GO:0051867	general adaptation syndrome, behavioral process
GO:0060078	regulation of postsynaptic membrane potential
GO:0071320	cellular response to cAMP
GO:0071805	potassium ion transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0030424	axon
GO:0030425	dendrite
GO:0034702	monoatomic ion channel complex
GO:0045211	postsynaptic membrane
GO:0048787	presynaptic active zone membrane
GO:0098855	HCN channel complex
GO:0098978	glutamatergic synapse

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:8t4m, PDBe:8t4m, PDBj:8t4m
PDBsum	8t4m
PubMed	38890331
UniProt	O60741\|HCN1_HUMAN Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (Gene Name=HCN1)

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