Structure of PDB 8t4h Chain A Binding Site BS01

Receptor Information
>8t4h Chain A (length=533) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLM
SILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRDTSTLSDSLSE
NLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQL
LEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN
QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQ
MQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDGLLTPLHLEGLVQFQDVS
FAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTG
GQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTM
EEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIR
KPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQA
DHILFLEGGAIREGGTHQQLMEKKGCYWAMVQA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8t4h Transporter associated with antigen processing (TAP) bound to the 8-mer peptide RRYQSTEL
Resolution3.8 Å
Binding residue
(original residue number in PDB)		E242 D246 E301 S304 L305 Y309 Y408 V460
Binding residue
(residue number reindexed from 1)		E61 D65 E100 S103 L104 Y108 Y207 V259
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015433 ABC-type peptide antigen transporter activity
GO:0023029 MHC class Ib protein binding
GO:0042288 MHC class I protein binding
GO:0042605 peptide antigen binding
GO:0042803 protein homodimerization activity
GO:0043531 ADP binding
GO:0046872 metal ion binding
GO:0046978 TAP1 binding
GO:0046979 TAP2 binding
GO:1904680 peptide transmembrane transporter activity
Biological Process
GO:0002250 adaptive immune response
GO:0006952 defense response
GO:0015031 protein transport
GO:0015833 peptide transport
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0046967 cytosol to endoplasmic reticulum transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane
GO:0034451 centriolar satellite
GO:0042824 MHC class I peptide loading complex
GO:0042825 TAP complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t4h, PDBe:8t4h, PDBj:8t4h
PDBsum8t4h
PubMed
UniProtQ03518|TAP1_HUMAN Antigen peptide transporter 1 (Gene Name=TAP1)

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