Structure of PDB 8t41 Chain A Binding Site BS01

Receptor Information
>8t41 Chain A (length=859) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALPNLTRDQAVERAALITVDSYQIILDVTDGNGAPGERTFRSTTTVVFDA
LPGADTVIDISAHTVRRASLNDQDLDVSGYDEAAGIPLRGLAQRNVVVVD
ADCHYSNTGEGLHRFVDPVDGETYLYSQFETADAKRMFACFDQPDLKATF
DVRVTAPAHWKVISNGAPLAAANGVHTFATTPRMSTYLVALIAGPYAAWT
DTYIDDHGEIPLGIYCRASLAEYMDAERLFTQTKQGFGFYHKHFGLPYAF
GKYDQLFVPEFNAGAMENAGAVTFLEDYVFRSKVTRASYERRAETVLHEM
AHMWFGDLVTMTWWDDLWLNESFATFASVLCQSEATEFTEAWTTFATVEK
SWAYRQDQLPSTHPIAADIPDLAAVEVNFDGITYAKGASVLKQLVAYVGL
ERFLAGLRDYFRTHAFGNASFDDLLAALEKASGRDLSNWGEQWLKTTGLN
TLRPDFEVDAEGRFTRFAVTQSGAAPGAGETRVHRLAVGIYDDDGSKSSG
KLVRVHREELDVSGPITNVPALVGVSRGKLILVNDDDLTYCSLRLDERSL
QTALDRIADIAEPLPRTLVWSAAWEMTREAELRARDFVSLVSGGVHAETE
VGVAQRLLLQAQTALGCYAEPGWARERGWPQFADRLLELAREAEPGSDHQ
LAYINSLCSSVLSPRHVQTLGALLEGEPAACGLAGLAVDTDLRWRIVTAL
ATAGAIDADGPETPRIDAEVQRDPTAAGKRHAAQARAARPQFVVKDEAFT
TVVEDDTLANATGRAMIAGIAAPGQGELLKPFARRYFQAIPGVWARRSSE
VAQSVVIGLYPHWDISEQGITAAEEFLSDPEVPPALRRLVLEGQAAVQRS
LRARNFDAD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain8t41 Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB8t41 Crystal structure of aminopeptidase N from Mycobacterium tuberculosis
Resolution1.45 Å
Binding residue
(original residue number in PDB)		H299 H303 E322
Binding residue
(residue number reindexed from 1)		H298 H302 E321
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.2: membrane alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8t41, PDBe:8t41, PDBj:8t41
PDBsum8t41
PubMed
UniProtL7N655

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