Structure of PDB 8t03 Chain A Binding Site BS01

Receptor Information

>8t03 Chain A (length=199) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

VAKLLLPTLSSLAFLPTVSIATKRRFYMEAMVYLFTMFFVAFSHACDGPG
LSVLCFMRRDILEYFSIYGTALSMWVSLMALADFDEPQRSTFTMLGVLTI
AVRTFHDRWGYGVYSGPIGTATLIIAVKWLKKMKEKKGLYPDKSIYTQQI
GPGLCFGALALMLRFFFEEWDYTYVHSFYHCALAMSFVLLLPKVNKKAG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8t03 Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8t03 Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Resolution	2.72 Å
Binding residue (original residue number in PDB)	H48 H180 H184
Binding residue (residue number reindexed from 1)	H44 H176 H180
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005515	protein binding

	Biological Process
GO:0007517	muscle organ development
GO:0007520	myoblast fusion
GO:0014905	myoblast fusion involved in skeletal muscle regeneration
GO:0043403	skeletal muscle tissue regeneration
GO:0045026	plasma membrane fusion
GO:1904206	positive regulation of skeletal muscle hypertrophy

	Cellular Component
GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Cellular Component

External links

PDB	RCSB:8t03, PDBe:8t03, PDBj:8t03
PDBsum	8t03
PubMed	37770716
UniProt	Q9D1N4\|MYMK_MOUSE Protein myomaker (Gene Name=Mymk)

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