Structure of PDB 8swi Chain A Binding Site BS01

Receptor Information

>8swi Chain A (length=451) Species: 91891 (Legionella pneumophila subsp. pneumophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NADEWIDTSKIMLDLHIDNMSSSDYIPSAIDRTDLVMVQSVHLLRKTGGR
GLFAREDIPKGTCIGIYTGEVYSEQEFEQYLKEHVGSDKSYAMYVGGRVI
DAARKGNLTRYINFSDSQDNAEFVETTLNRKKVAKVITTKNIKAGQQLLI
NYNTYEEQASRYYYFLNPGDGWLSAQEFYQTYQSQYRLEQMPYNLEGFDL
KAGDRVLMTQIGRIILANYSLAKEQELNASDIDLPFLKVGSDEKILDFDE
ADTFTPLMAACYLGQVENVKWLIEHGANIDQQQSHSGHCPLSLTLKGYSL
AKDTQKYIDIIQLLIKNQVNLLVHDRSDKTFLHNAALVLNNLDFQSVVKF
LIGQNPIDINEYFTYIDENDFDIVMHCYNNKLFDKALVLLAFYPDYFKRN
YMSDNEGHNQFNINAFRKAIKDFNSNERSILLMQLRESGLHLPEDLLEQL
G

Ligand information

>8swi Chain B (length=10) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ARTKQTKSTG

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8swi The SET and ankyrin domains of the secreted Legionella pneumophila histone methyltransferase work together to modify host chromatin.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	Y148 A173 M174 Y233 N234 Y236 D409 T445 Y446 I447 D448 D451 N493
Binding residue (residue number reindexed from 1)	Y67 A92 M93 Y152 N153 Y155 D328 T364 Y365 I366 D367 D370 N412

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8swi, PDBe:8swi, PDBj:8swi
PDBsum	8swi
PubMed	37795993
UniProt	Q5ZUS4

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