Structure of PDB 8sw1 Chain A Binding Site BS01

Receptor Information
>8sw1 Chain A (length=864) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADI
DIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVG
ELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATF
DISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVV
GEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPY
PLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVV
GHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFV
SADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHD
YIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQ
MGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSE
DPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLES
LLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYT
VWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGH
LDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLT
VLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFAL
SEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISR
LIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKR
DAESIHQYLLQRKA
Ligand information
Receptor-Ligand Complex Structure
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PDB8sw1 Structure of puromycin-sensitive aminopeptidase and polyglutamine binding.
Resolution3.65 Å
Binding residue
(original residue number in PDB)		E180 A315 A317 E319 E375 D430
Binding residue
(residue number reindexed from 1)		E130 A265 A267 E269 E325 D380
Enzymatic activity
Enzyme Commision number 3.4.11.14: cytosol alanyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0042277 peptide binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006508 proteolysis
GO:0043171 peptide catabolic process
GO:0071456 cellular response to hypoxia
GO:1903955 positive regulation of protein targeting to mitochondrion
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sw1, PDBe:8sw1, PDBj:8sw1
PDBsum8sw1
PubMed37440518
UniProtP55786|PSA_HUMAN Puromycin-sensitive aminopeptidase (Gene Name=NPEPPS)

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