Structure of PDB 8sr6 Chain A Binding Site BS01

Receptor Information

>8sr6 Chain A (length=451) Species: 91891 (Legionella pneumophila subsp. pneumophila) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NADEWIDTSKIMLDLHIDNMSSSDYIPSAIDRTDLVMVQSVHLLRKTGGR
GLFAREDIPKGTCIGIYTGEVYSEQEFEQYLKEHVGSDKSYAMYVGGRVI
DAARKGNLTRYINFSDSQDNAEFVETTLNRKKVAKVITTKNIKAGQQLLI
NYNTYEEQASRYYYFLNPGDGWLSAQEFYQTYQSQYRLEQMPYNLEGFDL
KAGDRVLMTQIGRIILANYSLAKEQELNASDIDLPFLKVGSDEKILDFDE
ADTFTPLMAACYLGQVENVKWLIEHGANIDQQQSHSGHCPLSLTLKGYSL
AKDTQKYIDIIQLLIKNQVNLLVHDRSDKTFLHNAALVLNNLDFQSVVKF
LIGQNPIDINEYFTYIDENDFDIVMHCYNNKLFDKALVLLAFYPDYFKRN
YMSDNEGHNQFNINAFRKAIKDFNSNERSILLMQLRESGLHLPEDLLEQL
G

Ligand information

>8sr6 Chain B (length=15) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TKQTARKSTGGKAPR

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8sr6 Histone methyltransferase activity of the secreted Legionella pneumophila SET-domain effector RomA/LegAS4 depends on its ankyrin domain
Resolution	2.22 Å
Binding residue (original residue number in PDB)	Y148 K170 A173 M174 Y175 F204 E206 Y233 N234 T235 Y236 E237 T445 Y446 I447 E449 D451 H489 F492 N493
Binding residue (residue number reindexed from 1)	Y67 K89 A92 M93 Y94 F123 E125 Y152 N153 T154 Y155 E156 T364 Y365 I366 E368 D370 H408 F411 N412

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:8sr6, PDBe:8sr6, PDBj:8sr6
PDBsum	8sr6
PubMed	37795993
UniProt	Q5ZUS4

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