Structure of PDB 8sqm Chain A Binding Site BS01

Receptor Information
>8sqm Chain A (length=1398) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CKLCRSPEGFGPISFYGDFTQCFIDGVILNLSAIFMITFGIRDLVNLCKK
KHSGIKYRRNWIIVSRMALVLLEIAFVSLASLNISKEEAENFTIVSQYAS
TMLSLFVALALHWIEYDRSVVANTVLLFYWLFETFGNFAKLINILIRHTY
EGIWYSGQTGFILTLFQVITCASILLLEALPKKPLMPTRRKPNPYDSANI
FSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENEL
KQKSNPSLSWAICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVTD
YNSERQDPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKS
ALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIWSG
PFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMKY
KDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCYM
AVTSFQFNIVPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPLM
IIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINIG
DDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGD
LFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKAC
ALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDDP
LAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDNG
EITQQGTYDEITKDADSPLWKLLREHREQGKVKWNIYLEYAKACNPKSVC
VFILFIVISMFLSVMGNVWLKHWSEVNSRYGSNPNAARYLAIYFALGIGS
ALATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNR
FSNDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVF
YIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFS
HINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQG
TLTAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSE
APLIVEGHRPPGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRT
GAGKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQV
FEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGG
NLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKD
RTILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSLC
Ligand information
>8sqm Chain B (length=14) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAAA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sqm Structure of a dimeric ABC transporter
Resolution3.4 Å
Binding residue
(original residue number in PDB)		E240 G714 H715
Binding residue
(residue number reindexed from 1)		E223 G685 H686
Enzymatic activity
Enzyme Commision number 7.2.2.2: ABC-type Cd(2+) transporter.
7.6.2.3: ABC-type glutathione-S-conjugate transporter.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008551 P-type cadmium transporter activity
GO:0015127 bilirubin transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015434 ABC-type cadmium transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0010038 response to metal ion
GO:0015723 bilirubin transport
GO:0042144 vacuole fusion, non-autophagic
GO:0045454 cell redox homeostasis
GO:0046686 response to cadmium ion
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0045121 membrane raft

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8sqm, PDBe:8sqm, PDBj:8sqm
PDBsum8sqm
PubMed
UniProtP39109|YCFI_YEAST Metal resistance protein YCF1 (Gene Name=YCF1)

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