Structure of PDB 8sql Chain A Binding Site BS01

Receptor Information
>8sql Chain A (length=1396) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CKLCRSPEGFGPISFYGDFTQCFIDGVILNLSAIFMITFGIRDLVNLCKK
KHSGIKYRRNWIIVSRMALVLLEIAFVSLASLNISKEEAENFTIVSQYAS
TMLSLFVALALHWIEYDRSVVANTVLLFYWLFETFGNFAKLINILIRHTY
EGIWYSGQTGFILTLFQVITCASILLLEALPKKPLMPHTRRKPNPYDSAN
IFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENE
LKQKSNPSLSWAICRTFGSKMLLAAFFKAIHDVLAFTQPQLLRILIKFVT
DYNSERQDPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIK
SALTALIYQKSLVLSNEASGLSSTGDIVNLMSVDVQKLQDLTQWLNLIWS
GPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLNSFLMRIQKKLQKSQMK
YKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGCY
MAVTSFQFNIVPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPL
MIIPMVLNSFIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINI
GDDATFLWQRKPEYKVALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLG
DLFRVKGFATVHGSVAYVSQVPWIMNGTVKENILFGHRYDAEFYEKTIKA
CALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAVYARADTYLLDD
PLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDN
GEITQQGTYDEITKDADSPLWKLLREQGKVKWNIYLEYAKACNPKSVCVF
ILFIVISMFLSVMGNVWLKHWSEVNSRYGSNPNAARYLAIYFALGIGSAL
ATLIQTIVLWVFCTIHASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFS
NDIYKVDALLGRTFSQFFVNAVKVTFTITVICATTWQFIFIIIPLSVFYI
YYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGYSQQKRFSHI
NQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTL
TAGMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKSEAP
LIVEGHRPPGDIKFNNYSTRYRPELDLVLKHINIHIKPNEKVGIVGRTGA
GKSSLTLALFRMIEASEGNIVIDNIAINEIGLYDLRHKLSIIPQDSQVFE
GTVRENIDPINQYTDEAIWRALELSHLKEHVLSMSNDGLDAQLTEGGGNL
SVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRT
ILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKSLFYSLC
Ligand information
>8sql Chain B (length=13) Species: 4932 (Saccharomyces cerevisiae) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
AAAAAAAAAAAAA
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sql Cleaved Ycf1p Monomer in the Beta Conformation
Resolution3.1 Å
Binding residue
(original residue number in PDB)		R206 G714 H715 R716 R770 K805 H1153 C1157
Binding residue
(residue number reindexed from 1)		R190 G686 H687 R688 R742 K777 H1049 C1053
Enzymatic activity
Enzyme Commision number 7.2.2.2: ABC-type Cd(2+) transporter.
7.6.2.3: ABC-type glutathione-S-conjugate transporter.
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008551 P-type cadmium transporter activity
GO:0015127 bilirubin transmembrane transporter activity
GO:0015431 ABC-type glutathione S-conjugate transporter activity
GO:0015434 ABC-type cadmium transporter activity
GO:0016887 ATP hydrolysis activity
GO:0042626 ATPase-coupled transmembrane transporter activity
GO:0140359 ABC-type transporter activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0010038 response to metal ion
GO:0015723 bilirubin transport
GO:0042144 vacuole fusion, non-autophagic
GO:0045454 cell redox homeostasis
GO:0046686 response to cadmium ion
GO:0055085 transmembrane transport
GO:0070574 cadmium ion transmembrane transport
Cellular Component
GO:0000329 fungal-type vacuole membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0016020 membrane
GO:0045121 membrane raft

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8sql, PDBe:8sql, PDBj:8sql
PDBsum8sql
PubMed
UniProtP39109|YCFI_YEAST Metal resistance protein YCF1 (Gene Name=YCF1)

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