Structure of PDB 8snx Chain A Binding Site BS01

Receptor Information
>8snx Chain A (length=1386) Species: 1972429 (Respiratory syncytial virus A2) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANVYLTDSYLKGVISFSECNALGSYIFNGPYLKNDYTNLISRQNPLIEHM
NLKKLNITQSLISKYHKGEIKLEEPTYFQSLLMTYKSMTSSEQIATTNLL
KKIIRRAIEISDVKVYAILNKLGLTIKTTLLKKLMCSMQHPPSWLIHWFN
LYTKLNNILTQYRSNEVKNHGFTLIDNQTLSGFQFILNQYGCIVYHKELK
RITVTTYNQFLTWKDISLSRLNVCLITWISNCLNTLNKSLGLRCGFNNVI
LTQLFLYGDCILKLFHNEGFYIIKEVEGFIMSLILNITEEDQFRKRFYNS
MLNNITDAANKAQKNLLSRVCHTLLDKTVSDNIINGRWIILLSKFLKLIK
LAGDNNLNNLSELYFLFRIFGHPMVDERQAMDAVKINCNETKFYLLSSLS
MLRGAFIYRIIKGFVNNYNRWPTLRNAIVLPLRWLTYYKLNTYPSLLELT
ERDLIVLSGLRFYREFRLPKKVDLEMIINDKAISPPKNLIWTSFPRNYMP
SHIQNYIEHEKLKFSESDKSRRVLEYYLRDNKFNECDLYNCVVNQSYLNN
PNHVVSLTGKERELSVGRMFAMQPGMFRQVQILAEKMIAENILQFFPESL
TRELQKILELKAGNYISKCSIITDLSKFNQAFRYETSCICSDVLDELHGV
QSLFSWLHLTIPHVTIICTYRHAPPYIGDHIVDLNNVDEQSGLYRYHMGG
IEGWCQKLWTIEAISLLDLISLKGKFSITALINGDNQSIDISKPIRLMEG
QTHAQADYLLALNSLKLLYKEYAGIGHKLKGTETYISRDMQFMSKTIQHN
GVYYPASIKKVLRVGPWINTILDDFKVSLESIGSLTQELEYRGESLLCSL
IFRNVWLYNQIALQLKNHALCNNKLYLDILKVLKHLKTFFNLDNIDTALT
LYMNLPMLFGGGDPNLLYRSFYRRTPDFLTEAIVHSVFILSYYTNHDLKD
KLQDLSDDRLNKFLTCIITFDKNPNAEFVTLMRDPQALGSERQAKITSEI
NRLAVTEVLSTAPNKIFSKSAQHYTTTEIDLNDIMQNIEPTYPHGLRVVY
ESLPFYKAEKIVNLISGTKSITNILEKTSAIDLTDIDRATEMMRKNITLL
IRILPLDCNRDKREILSMENLSITELSKYVRERSWSLSNIVGVTSPSIMY
TMDIKYTTSTISSGIIIEKYNVNSLTRGERGPTKPWVGSSTQEKKTMPVY
NRQVLTKKQRDQIDLLAKLDWVYASIDNKDEFMEELSIGTLGLTYEKAKK
LFPQYLSVNYLHRLTVSSRPCEFPASIPAYRTTNYHFDTSPINRILTEKY
GDEDIDIVFQNCISFGLSLMSVVEQFTNVCPNRIILIPKLNEIHLMKPPI
FTGDVDIHKLKQVIQKQHMFLPDKISLTQYVELFLS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8snx Structures of the promoter-bound respiratory syncytial virus polymerase
Resolution3.4 Å
Binding residue
(original residue number in PDB)		Y13 E57 Y249 K540 A541 T551 F553 P554 R555 I566 S579 R580 R581 E584 K619 E620 F629 A630 M631 R637 Q640 T660 R747 E778 G779 K783 K1153 S1155
Binding residue
(residue number reindexed from 1)		Y4 E48 Y190 K481 A482 T492 F494 P495 R496 I507 S520 R521 R522 E525 K560 E561 F570 A571 M572 R578 Q581 T601 R671 E702 G703 K707 K1077 S1079
Enzymatic activity
Enzyme Commision number 2.1.1.375: NNS virus cap methyltransferase.
2.7.7.48: RNA-directed RNA polymerase.
2.7.7.88: GDP polyribonucleotidyltransferase.
3.6.1.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0016787 hydrolase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006139 nucleobase-containing compound metabolic process
GO:0006370 7-methylguanosine mRNA capping
GO:0032259 methylation
GO:0039689 negative stranded viral RNA replication
GO:0106005 RNA 5'-cap (guanine-N7)-methylation
Cellular Component
GO:0030430 host cell cytoplasm
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8snx, PDBe:8snx, PDBj:8snx
PDBsum8snx
PubMed38123676
UniProtP28887|L_HRSVA RNA-directed RNA polymerase L (Gene Name=L)

[Back to BioLiP]