Structure of PDB 8slw Chain A Binding Site BS01

Receptor Information
>8slw Chain A (length=921) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CKGEVNFKRSKFVKVPSNVAPSMLFELLLTEWHLPAPNLVVSLVGEERLF
AMKSWLRDVLRKGLVKAAQSTGAWILTSALHVGLARHVGQAVRDHSLAVR
VVAIGMASLDRILHRQLLDGTPIHYPADLCPLDSNLSHFILVLAELQLSL
EKHISQQRTGSSIQIPVLCLLVNGDPSTLERMSRAVEQAAPWLILAGSGG
IADVLAALVGQPHLLVPQVTEKQFREKFPSECFSWEAIVHWTELLQNIAA
HPHLLTVYDFEQEGSEDLDTVILKALVKACKSHSRDAQDYLDELKLAVAW
DRVDIAKSEIFNGDVEWKSCDLEEVMTDALVSNKPDFVRLFVDSGADMAE
FLTYGRLQQLYHSVSPKSLLFELLERKHEEGRLLPAFSLHEVSRVLKDFL
HDACRGFYQDWLPDLSRKSEDPWRDLFLWAVLQNRYEMATYFWAMGREGV
AAALAACKIIKEMSHLEKEAEVARTMREAKYEQLALDLFSECYSNSEDRA
FALLVRRNHSWSRTTCLHLATEADAKAFFAHDGVQAFLTKIWWGDMATGT
PILRLLGAFTCPALIYTNLISFSEAAFLLTRWRKFWGAPVTVFLGNVVMY
FAFLFLFSYVLLVDFRPPPQGPSGSEVTLYFWVFTLVLEEIRQGFFTDTR
LVKKFTLYVEDNWNKCDMVAIFLFIVGVTCRMVPSVFEAGRTVLAIDFMV
FTLRLIHIFAIHKQLGPKIIIVERMMKDVFFFLFFLSVWLVAYGVTTQAL
LHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVANWLVILLLVTFL
LVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYHLIVEYHGRPALAPP
FILLSHLSLVLKQVFRHLERDLPDPVDQKIITWETVQKENFLSTMEKRRR
DSEEEVLRKTAHRVDLIAKYI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain8slw Chain A Residue 1201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8slw Structural dynamics at cytosolic interprotomer interfaces control gating of a mammalian TRPM5 channel.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		Q225 D350 D353 E354
Binding residue
(residue number reindexed from 1)		Q164 D289 D292 E293
Annotation score4
External links