Structure of PDB 8skt Chain A Binding Site BS01
Receptor Information
>8skt Chain A (length=356) Species:
10090
(Mus musculus) [
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DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRINPLSH
FLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRN
PEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPK
NAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKL
MKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFD
KLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNG
FPIFDK
Ligand information
>8skt Chain E (length=18) [
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atctgtacatgtacagat
Receptor-Ligand Complex Structure
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PDB
8skt
Structure of ternary complex of mouse cGAS with dsDNA and bound ATP with 5 mM Mn2+
Resolution
2.69 Å
Binding residue
(original residue number in PDB)
R158 L159 R161 K162 H203 E386 K395
Binding residue
(residue number reindexed from 1)
R11 L12 R14 K15 H56 E236 K245
Enzymatic activity
Enzyme Commision number
2.7.7.86
: cyclic GMP-AMP synthase.
External links
PDB
RCSB:8skt
,
PDBe:8skt
,
PDBj:8skt
PDBsum
8skt
PubMed
38740774
UniProt
Q8C6L5
|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)
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