Structure of PDB 8sdz Chain A Binding Site BS01

Receptor Information
>8sdz Chain A (length=500) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AFNDLLKQVGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHHCRP
PANANLGGLEAWLPLDKQGQPESCLRFTSPQRVTEPCIDGWVYDNSTFPS
TIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILN
YLQTAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHT
RAYVGTLIGYVYSLGQFLLAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFF
IESARWYSSSGRLDLTLRALQRVARINGKQEEGAKLSIEVLRTSLQKELA
SAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSMYLIQVIF
GAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIPKSHTIIRT
SLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSPL
VSMTAEFYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSR
Ligand information
Ligand IDRTO
InChIInChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChIKeyDBABZHXKTCFAPX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCN(CCC)[S](=O)(=O)c1ccc(cc1)C(O)=O
OpenEye OEToolkits 3.1.0.0CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O
FormulaC13 H19 N O4 S
Name4-(dipropylsulfamoyl)benzoic acid
ChEMBLCHEMBL897
DrugBankDB01032
ZINCZINC000000001982
PDB chain8sdz Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8sdz The substrate and inhibitor binding mechanism of polyspecific transporter OAT1 revealed by high-resolution cryo-EM
Resolution2.86 Å
Binding residue
(original residue number in PDB)		Y354 K382 F438 R466 S469
Binding residue
(residue number reindexed from 1)		Y330 K358 F414 R442 S445
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008514 organic anion transmembrane transporter activity
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015139 alpha-ketoglutarate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity
GO:0022857 transmembrane transporter activity
GO:0031404 chloride ion binding
GO:0042802 identical protein binding
GO:0042910 xenobiotic transmembrane transporter activity
Biological Process
GO:0006820 monoatomic anion transport
GO:0014070 response to organic cyclic compound
GO:0015698 inorganic anion transport
GO:0015711 organic anion transport
GO:0015732 prostaglandin transport
GO:0015742 alpha-ketoglutarate transport
GO:0042908 xenobiotic transport
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport
GO:0072237 metanephric proximal tubule development
GO:0097254 renal tubular secretion
Cellular Component
GO:0005886 plasma membrane
GO:0005901 caveola
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0032991 protein-containing complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8sdz, PDBe:8sdz, PDBj:8sdz
PDBsum8sdz
PubMed37845412
UniProtO35956|S22A6_RAT Solute carrier family 22 member 6 (Gene Name=Slc22a6)

[Back to BioLiP]