Structure of PDB 8s52 Chain A Binding Site BS01

Receptor Information
>8s52 Chain A (length=1420) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDP
RQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCV
CFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGCGR
YQPRIRRSGLELYAEWKKILLSPERVHEIFKRISDEECFVLGMEPRYARP
EWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQ
NGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKG
KEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVT
PFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYK
VERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNAD
FDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAV
RKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLI
IPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSL
GTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIAD
SKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRIL
NDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEG
KRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGRE
GLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDG
LAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSN
AHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFH
INPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHL
RSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSL
GEPATQMTLNKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERA
KDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDV
ARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEK
LVLRIRIMNSKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNK
KKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFT
VLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRH
GVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAG
TGCFDLLLDAEKCKYGMEIP
Ligand information
>8s52 Chain N (length=53) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gaaggggggctataaaagggggtgggggcggcaattttgacagcgagggc
cag
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8s52 Three-step mechanism of promoter escape by RNA polymerase II
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y145 K149 R190 H1417
Binding residue
(residue number reindexed from 1)		Y135 K139 R154 H1350
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006366 transcription by RNA polymerase II
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0031981 nuclear lumen
GO:0032991 protein-containing complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8s52, PDBe:8s52, PDBj:8s52
PDBsum8s52
PubMed38604172
UniProtA0A7M4DUC2

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