Structure of PDB 8s31 Chain A Binding Site BS01

Receptor Information
>8s31 Chain A (length=227) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDY
SDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSS
HPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRT
RSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLL
EEYGCCKELASRLRYARTMVDKLLSSR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8s31 PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance.
Resolution2.134 Å
Binding residue
(original residue number in PDB)		W414 V415 D416 E488 H489 L490 L491 R516 H538 K540
Binding residue
(residue number reindexed from 1)		W47 V48 D49 E121 H122 L123 L124 R149 H171 K173
External links
PDB RCSB:8s31, PDBe:8s31, PDBj:8s31
PDBsum8s31
PubMed39236175
UniProtP53350|PLK1_HUMAN Serine/threonine-protein kinase PLK1 (Gene Name=PLK1)

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