Structure of PDB 8ru3 Chain A Binding Site BS01

Receptor Information

>8ru3 Chain A (length=507) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSKKEASRHAIMRSPQMVS
AIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPALVKMLGS
PVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAI
TTDCLQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKV
LSVCSSNKPAIVEAGGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQE
GMEGLLGTLVQLLGSDDINVVTCAAGILSNLTCNNYKNKMMVCQVGGIEA
LVRTVLRAGDREDITEPAICALRHLTSRHQEAEMAQNAVRLHYGLPVVVK
LLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLLVRAHQD
TQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFVQLLYSPI
ENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAA
VLFRMSE

Ligand information

>8ru3 Chain P (length=12) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ESILDEHLQRVW

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8ru3 Structure-Based Design of Bicyclic Helical Peptides That Target the Oncogene beta-Catenin.
Resolution	2.001 Å
Binding residue (original residue number in PDB)	H223 F253 Y254 T257 H260 N261 N290 K292 I296 T339
Binding residue (residue number reindexed from 1)	H77 F107 Y108 T111 H114 N115 N144 K146 I150 T193

External links

PDB	RCSB:8ru3, PDBe:8ru3, PDBj:8ru3
PDBsum	8ru3
PubMed	39167026
UniProt	P35222\|CTNB1_HUMAN Catenin beta-1 (Gene Name=CTNNB1)

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