Structure of PDB 8rqc Chain A Binding Site BS01

Receptor Information
>8rqc Chain A (length=300) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEEFRTLHDDDSIQVIPVLPQVMMILVPGQTLPLQLFHPQEVSMVRNLIQ
NDRTFAVLAYSNVQEAEFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKV
LELRTQSDGIQQAKVQILPEGSGDAETLMDRIKKQLREWDENLKDDSLPS
NPIDFSYWVAANLPIDDSLRIQLLKIDSAIQRLRCELDIMNKCTSLCCKQ
CQETEITTKNEIFSLSREGPMAAYVNPHGYVHEILTVYKACNLNLIGRPS
TEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALIPT
Ligand information
>8rqc Chain B (length=27) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PFQCNQCGASFTQKGNLLRHIKLHSGE
Receptor-Ligand Complex Structure
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PDB8rqc Design of a Cereblon construct for crystallographic and biophysical studies of protein degraders
Resolution2.15 Å
Binding residue
(original residue number in PDB)		Q325 N351 H353 Y355 I371 W386 V388 H397 W400
Binding residue
(residue number reindexed from 1)		Q200 N226 H228 Y230 I246 W261 V263 H272 W275
External links
PDB RCSB:8rqc, PDBe:8rqc, PDBj:8rqc
PDBsum8rqc
PubMed
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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