Structure of PDB 8ro0 Chain A Binding Site BS01

Receptor Information
>8ro0 Chain A (length=2231) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSILEEKSRKWKQLQGKRYSEKKKFGMSDTQKEEMPPEHVRKVIRDHGDM
TSRKYRHDKRVYLGALKYMPHAVLKLLENMPMPWEQIRDVKVLYHITGAI
TFVNDIPRVIEPVYMAQWGTMWIMMRREKRDRRHFKRMRFPPFDDEEPPL
DYADNILDVEPLEPIQMELDPEEDGAVAEWFYDHKPLATTRFVNGPTYRK
WAFSIPQMSTLYRLANQLLTDLVDDNYFYLFDMKSFFTAKALNVAIPGGP
KFEPLVKDLHTDEDWNEFNDINKVIIRAPIRTEYRIAFPFMYNNLISSLP
VQVSWYHTPSVVFIKTEDPDLPAFYYDPLINPIVLSNLKATEENLPEGEE
EDEWELPEDVRPIFEDVPLYTDNTANGLALLWAPRPFNLRSGRTRRAVDV
PLVKSWYREHCPAGMPVKVRVSYQKLLKVFVLNALKHRPPKPQKRRYLFR
SFKATKFFQTTTLDWVEAGLQVLRQGYNMLNLLIHRKNLNYLHLDYNFNL
KPVKTLTTKERKKSRFGNAFHLCREILRLTKLVVDAHVQYRLNNVDAYQL
ADGLQYIFAHVGQLTGMYRYKYKLMRQVRMCKDLKHLIYYRFNTGPVGKG
PGCGFWAPGWRVWLFFLRGITPLLERWLGNLLSRQFEGRHSKGVAKTVTK
QRVESHFDLELRAAVMHDILDMMPDGIKQNKARVILQHLSEAWRCWKANI
PWKVPGLPTPVENMILRYVKAKADWWTNSAHYNRERVRRGATVDKTVCKK
NLGRLTRLYLKSEQERQHNYLKDGPYISAEEAVAIYTTTVHWLESRRFSP
IPFPPLSYKHDTKLLILALERLKESYSVKNRLNQSQREELALIEQAYDNP
HEALSRIKRHMLTQRAFKEVGIEFMDLYTHLIPVYDIEPLEKVTDAYLDQ
YLWYEADKRRLFPAWVKPGDTEPPPLLTYKWCQGLNNLQDVWETSEGECN
VIMETKLEKIAEKMDLTLLNRLLRLIVDHNIADYMTSKNNVLINYKDMNH
TNSFGIIRGLQFASFIVQFYGLVLDLLVLGLRRASEIAGPPQCPNEFLQF
QDVATEIGHPIRLYCRYIDRVWIMFRFSADEARDLIQRYLTEHPDPNNEN
IVGYNNKKCWPRDARMRLMKHDVNLGRAVFWDIKNRLPRSITTVEWENSF
VSVYSKDNPNMLFDMSGFECRILPKCRTANEEFVHRDGVWNLQNEVTKER
TAQCFLKVDEESLSKFHNRIRQILMSSGSTTFTKIVNKWNTALIGLMTYF
REAVVNTQELLDLLVKCENKIQTRIKIGLNSKMPSRFPPVVFYTPKEIGG
LGMLSMGHVLIPQSDLRWMQQTEAGGVTHFRSQLIPNLYRYIQPWEAEFV
DSVRVWAEYALKRQEANAQNRRLTLEDLDDSWDRGIPRINTLFQKDRHTL
AYDKGWRVRTEFKAYQILKQNPFWWTHQRHDGKLWNLNNYRTDMIQALGG
VEGILEHTLFRGTYFPTWEGLFWERASGFEESMKFKKLTNAQRSGLNQIP
NRRFTLWWSPTINRANVYVGFQVQLDLTGIFMHGKIPTLKISLIQIFRAH
LWQKIHESVVMDLCQVFDQELDALEIQTVQKETIHPRKSYKMNSSCADVL
LFAQYKWNVSRPSLMADSKDVMDNTTTQKYWLDVQLRWGDYDSHDVERYA
RAKFLDYTTDNMSIYPSPTGVLIAIDLAYNLYSAYGNWFPGMKPLIRQAM
AKIIKANPAFYVLRERIRKGLQLYSSENYGELFSNQIIWFVDDTNVYRVT
IHKTFEGNLTTKPINGAIFIFNPRTGQLFLKIIHTSVWAGQKRLSQLAKW
KTAEEVAALIRSLPVEEQPRQIIVTRKAMLDPLEVHLLDFPNIVIKGSEL
MLPFQAIMKVEKFGDLILKATEPQMVLFNLYDDWLKTISSYTAFSRVVLI
MRGMHINPDKTKVILKPDKTTITEPHHIWPTLSDDDWIKVELALKDMILA
DYGKKNNVNVASLTQSEVRDIILGMEISAPSQQEWRVRAISSTNLHLRTQ
HIYVNSDDVKDTGYTYILPKNILKKFITISDLRTQIAGFMYGVSPPDNPQ
VKEIRCIVLVPQTGSHQQVNLPTQLPDHELLRDFEPLGWMHTQPNELPQL
SPQDVTTHAKLLTDNISWDGEKTVMITCSFTPGSVSLTAYKLTPSGYEWG
KANTDKGNNPKGYMPTHYEKVQMLLSDRFLGYFMVPSNGVWNYNFQGQRW
SPAMKFDVCLSNPKEYYHEDHRPVHFHNFKA
Ligand information
>8ro0 Chain 2 (length=61) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcuucuucggcuuagcuaagaucuuuuuuuuuuuuuuuuuuuuuuuuuu
uuuuuuuuuuu
..................................................
...........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8ro0 Mechanism for the initiation of spliceosome disassembly.
Resolution2.9 Å
Binding residue
(original residue number in PDB)
D674 R678 R699 Q703 K713 K766 R770 R773 N849 K1012
Binding residue
(residue number reindexed from 1)
D658 R662 R683 Q687 K697 K750 R754 R757 N833 K996
External links
PDB RCSB:8ro0, PDBe:8ro0, PDBj:8ro0
PDBsum8ro0
PubMed38925148
UniProtP34369|PRP8_CAEEL Pre-mRNA-splicing factor 8 homolog (Gene Name=prp-8)

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