Structure of PDB 8rhr Chain A Binding Site BS01

Receptor Information

>8rhr Chain A (length=168) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HMSVLQVLHIPDERLRKVAKPVEEVNAEIQRIVDDMFETMYAEEGIGLAA
TQVDIHQRIIVIDVSENRDERLVLINPELLEKSGETGIEEGCLSIPEQRA
LVPRAEKVKIRALDRDGKPFELEADGLLAICIQHEMDHLVGKLFMDYLSP
LKQQRIRQKVEKLDRLKA

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

8rhr Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	8rhr Toward More Selective Antibiotic Inhibitors: A Structural View of the Complexed Binding Pocket of E. coli Peptide Deformylase.
Resolution	1.42 Å
Binding residue (original residue number in PDB)	C90 H132 H136
Binding residue (residue number reindexed from 1)	C92 H134 H138
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.1.88: peptide deformylase.

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0008198	ferrous iron binding
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0042586	peptide deformylase activity
GO:0043022	ribosome binding
GO:0046872	metal ion binding

	Biological Process
GO:0006412	translation
GO:0043686	co-translational protein modification

	Cellular Component
GO:0005829	cytosol

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External links

PDB	RCSB:8rhr, PDBe:8rhr, PDBj:8rhr
PDBsum	8rhr
PubMed	38574272
UniProt	P0A6K3\|DEF_ECOLI Peptide deformylase (Gene Name=def)

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